Post-Doctoral Associate in Cancer Bioengineering
Company: University of Minnesota
Location: Minneapolis
Posted on: September 3, 2024
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Job Description:
Apply for JobJob ID346715
LocationTwin Cities
Job FamilyAcademic
Full/Part TimeFull-Time
Regular/TemporaryRegular
Job Code9546
Employee ClassAcad Prof and Admin
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About the Job
We have an opening for a postdoctoral researcher (funded by a
multi-PI NIH R01 grant), available immediately in the Department of
Biomedical Engineering and the Masonic Cancer Center at the
University of Minnesota-Twin Cities. The objective of this team
science project is to elucidate the role of the metastatic niche in
regulating tumor cell fate decisions towards dormancy and
colonization. This project will explore the interplay between
extracellular matrix and stroma in metastatic sites in concert with
tumor-specific genetic programming that regulates dormancy. This
work will leverage a novel tissue engineering platform that allow
for culture of metastatic tumor cells within 3D micro-engineered
metastatic environments (MEMEs) and sorting of MEMEs based on cell
dormancy state using multiphoton flow cytometry (MPFC). This
multiplexed high throughput 3D platform permits screening of
microenvironmental factors, including ECM and stroma, and tumor
cell genetics via RNAseq and CRISPR screens. The postdoctoral
researcher will use these novel new tools to perform Transcriptome
analysis, Forward-genetics screens, and CRISPR screens in order to
define the mechanistic
drivers of disseminated tumor cell dormancy and proliferation in
distinct environments. This information will then be used with in
vitro and in vivo experiments to elucidate molecular mechanism and
identify therapeutic targets to prevent dormant tumor cells from
evading therapy and/or inhibit their escape from dormancy, thus
preventing recurrence.
These studies sit at the intersection of cancer biology, genomic
engineering, tissue engineering, and advanced quantitative imaging.
Thus, the successful applicant will be a part of an integrated
multidisciplinary team. The fellow will be co-mentored by Paolo
Provenzano, Associate Professor of Biomedical Engineering and
director of the Laboratory for Engineering Oncology, and Dave Wood,
Associate Professor of Biomedical Engineering and director of the
Living Devices Laboratory, along with Dr. David Largaespada,
Professor and Director of the Center for Genome Engineering. The
Laboratory for Engineering Oncology studies the physical and
molecular mechanisms driving cancer progression to metastasis and
and develops therapeutic strategies to overcome therapeutic
resistance. The Living Devices Laboratory combines expertise in
microfluidics, microfabrication, and tissue engineering to create
advanced in vitro model systems to study disease mechanisms and to
develop new therapies. The Largaspada lab identifies genetic
drivers of cancer and develops genetics assays and novel genome
engineering approaches to understand and treat cancer. The
successful candidate will work with personnel in multiple
laboratories, which are housed in adjacent space in the Nils
Hasselmo Hall, as well as with personnel in the laboratories of
David Largaespada and Kaylee Schwertfeger in the Masonic Cancer
Center.
Qualifications
Required:
those hypotheses. Successful candidates will also have excellent
communication and organizational skills, creative approaches to
experimental design, and must be able to work collaboratively.
About the Department
The University of Minnesota is robust research environment (ranked
8 th among public universities and 13 th overall in research
expenditures; NSF) and the applicant will work in the Department of
Biomedical Engineering (a top 20 ranked department), the Masonic
Cancer Center (an NCI designated Comprehensive Cancer Center), and
the UMN Physical Sciences in Oncology Center.
How To Apply
Applications must be submitted online. To be considered for this
position, please click the Apply button and follow the
instructions. You will be given the opportunity to complete an
online application for the position and attach a cover letter and
resume.Additional documents may be attached after application by
accessing your "My Job Applications" page and uploading documents
in the "My Cover Letters and Attachments" section.To request an
accommodation during the application process, please e-mail
employ@umn.edu or call (612) 624-UOHR (8647).
Diversity
The University recognizes and values the importance of diversity
and inclusion in enriching the employment experience of its
employees and in supporting the academic mission. The University is
committed to attracting and retaining employees with varying
identities and backgrounds.The University of Minnesota provides
equal access to and opportunity in its programs, facilities, and
employment without regard to race, color, creed, religion, national
origin, gender, age, marital status, disability, public assistance
status, veteran status, sexual orientation, gender identity, or
gender expression. To learn more about diversity at the U:
http://diversity.umn.edu.
Employment Requirements
Any offer of employment is contingent upon the successful
completion of a background check. Our presumption is that
prospective employees are eligible to work here. Criminal
convictions do not automatically disqualify finalists from
employment.
About the U of M
The University of Minnesota, Twin Cities (UMTC)The University of
Minnesota, Twin Cities (UMTC), is among the largest public research
universities in the country, offering undergraduate, graduate, and
professional students a multitude of opportunities for study and
research. Located at the heart of one of the nation's most vibrant,
diverse metropolitan communities, students on the campuses in
Minneapolis and St. Paul benefit from extensive partnerships with
world-renowned health centers, international corporations,
government agencies, and arts, nonprofit, and public service
organizations.
Keywords: University of Minnesota, Minneapolis , Post-Doctoral Associate in Cancer Bioengineering, Other , Minneapolis, Minnesota
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